Joint Clinical Research Centre

JCRC - CWRU Research Collaboration

Collaborations with the Case Western Reserve University (CWRU), Ohio USA and Makerere University College of Health Sciences (MAK CHS), commenced in 1998, and to date, a number of laboratory-based and clinical trials have been conducted under this partnership:

Delaying HIV Disease Progression with Punctuated ARV Therapy in patients with TB in Uganda - the PART study. This commenced in 2004 to date. JCRC Kampala is acting as the reference laboratory for all samples from this study.
A pilot study to evaluate Nucleic Acid Amplification test to predict relapse of TB and monitor the effectiveness of treatment (NAA). This study started in 2003 and is being implemented in collaboration with the MAK-CWRU collaboration. All samples from this study are being processed at the JCRC Kampala laboratory.
A non-comparative study of Efficacy of a largely-intermittent regimen among patients who will not receive Isoniazid due to the presence of initial Isoniazid resistance or intolerance. This is a concluded study. Again, the JCRC research laboratory was instrumental in processing all laboratory samples from this study.
An evaluation of the activity and tolerability of Moxifloxacin during the first two months of treatment for pulmonary TB: A double-blind, randomized, multicenter study by the TB trials Consortium (TBTC 027). This study is still on-going, since 2003. Patients' samples are processed at the JCRC research laboratory.
Evaluation of a Moxifloxacin Based, Isoniazid-Sparing regimen for TB Treatment (TBTC Study 28). This study is still on-going, since 2005. Patients' samples are processed at the JCRC research laboratory.
TBTC Study 29 "Evaluation of a Rifapentine-Containing Regimen for Intensive Phase Treatment of Pulmonary Tuberculosis. This study is still on-going, since 2008. Patients' samples are processed at the JCRC research laboratory.
A Pilot Study to Evaluate Nucleic Acid Amplification and Other Tests to Predict Relapse of Tuberculosis and Monitor the Effectiveness of Treatment (NAA 2M). Commenced in 2008 to date. JCRC collaborates with the MAK-CWRU partnership to process patients' samples collected from the study.
Determination of infection with multiple strains of mycobacterium TB in patients with pulmonary TB in Kampala, Uganda. This study commenced in 2008 and is now concluded. All samples were processed at the JCRC TB research laboratory.
Renal Disease in HIV-Infected Ugandans (HIV-Associated Nephropathy). This was an observational investigation conducted among patients attending JCRC in 2007. Results are currently being published.