Joint Clinical Research Centre

Study Acronymn	Full Study Name	Brief description
Anaemia Study	A Pilot Study on the use of Low Dose Erythropoietin in the Management of HIV Associated Anaemia	This was a four-week randomized clinical trial conducted among HIV positive patients with grade 1 to 2 anaemia to determine the effect of low dose erythropoietin on the patients' hemoglobin and their quality of life.
HPTN 027		This was a multi site phase I HIV vaccine trial in new born children to mothers infected with HIV. The aim of the trial was to evaluate the safety and tolerance and the immunogenicity of the ALVAC- HIV vCP1521 in new born infants to HIV positive mothers.
ARROW PK Study	Pharmacokinetics and acceptability of once- versus twice-daily lamivudine and abacavir in HIV-infected Ugandan children	This was conducted as a Pharmacokinetic sub-study within the ARROW trial. Results were published and can be accessed here.
ATRIPLA Food study	ATRIPLA Food study	This was a pharmacokinetic study investigating the effect of food on the bioavailability of the active components of the fixed drug combination of TDF/FTC/EFV.
JTV Study	Safety and Immunogenicity of LFn-P24C in HIV infected Adult Ugandan Volunteers who undergo monitored treatment interruption	This was a phase I therapeutic vaccine clinical trial, aiming at describing the safety of a boosted dose of LFn-p24C administered to HIV-1 infected subjects who have received at least 3 doses of LFn-p24C and who had plasma HIV-1 RNA levels < 400 copies/ml on ART; and to measure the effects of LFn-p24C on plasma RNA and HIV-specific immune response after a closely monitored 4 weeks of treatment interruption.
CD8 Study	CD8 Study	This was a cross-sectional, observational study lab-based to evaluate the prevalence of positive response to selected CD8 antigens. Plasma and PBMC were obtained from blood. PBMC were then used for ELISPOT
Chemokine / Cytokine studies		This encompassed a number of lab-based studies which included: Pleural- CT4, CT 12, CT14 and CT16 studies. Studies CT12, CT14 and CT16 have been completed.
DART study	Developing an Antiretroviral therapy for Africa	This study investigated the monitoring strategy for adults initiating ART in Africa: whether it is safe and cost effective to deliver ART without the use of routine laboratory blood tests. The Study findings have been published, and can be accessed here.
Pleural study (CT4)		This was a cross sectional study, aiming at investigating the role of different mechanisms of activation of HIV-1 at the sites of MTB infection in patients with HIV and pleural TB. A total number of 141 patients were enrolled.
SARA Study		This was a follow on study from the DART study, which evaluated the ART switch strategy for patients starting second line ART.
Pleural Study (CD4)		This was a cross sectional study, aiming at investigating the role of different mechanisms of activation of HIV-1 at the sites of MTB infection in patients with HIV and pleural TB. A total number of 141 patients were enrolled.
TU Study		This was a cross sectional study aimed at characterizing T-cell responses to mycobacterium Tuberculosis antigens in children 10 years or below with localized or disseminated TB. A total of 388 children were enrolled. Plasma and PBMC were obtained from blood. PBMC were then used for ELISPOT