Amendment: The role of Trained Immunity and Mitochondrial dysfunction on INnate immunity in children and adolescents aGing with PHIV (TIMING-PHIV)’
Description:
The impact of inflammation on non-AIDS co-morbidities in children may be greater in Sub-Saharan Africa due to co-infections, nutritional status variations and other factors.
This TIMING study will measure innate immune profiles (monocytes and natural killer cells), in adolescents with and without HIV in Uganda and USA. The study will also identify the role of trained immunity in innate immune modulation in adolescents with and without HIV.
Expected impact: Identification of targets for novel interventions to decrease inflammatory consequences and improve the children’s quality of life.
