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SPARKLE

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Crizanlizumab is a potent and selective IgG2 (immunoglobulin G2) kappa humanized monoclonal antibody that binds to human P-selectin with high affinity, blocking its interaction with its ligands, including P-selectin glycoprotein…
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TIMING

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Amendment: The role of Trained Immunity and Mitochondrial dysfunction on INnate immunity in children and adolescents aGing with PHIV (TIMING-PHIV)’ Description: The impact of inflammation on non-AIDS co-morbidities in children…
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HIBISCUS

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The combination of anti-sickling effects, decreased haemolysis and improved red blood cell (RBC) membrane integrity due to etavopivat treatment is proposed to improve RBC health and reduce the onset and…
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OTAC

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Outpatient Treatment with Anti-Coronavirus Immunoglobulin (OTAC) (INSIGHT 012) Coronavirus disease 2019 (COVID-19) is a predominantly respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and causes substantial morbidity…
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MUTIMA STUDY

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Preliminary data suggests a probable effect of HIV on myocardial fibrosis and steatosis in women, with inflammation being a key driver of fibrosis and metabolic dysfunction. The primary objective of…
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MAMO1 Study

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Despite the availability of multiple public health interventions, approximately 608,000 malaria deaths were recorded in 2022, with the majority of these deaths occurring in children under 5 years of age.…
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IMPALA

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Improving HIV Outcomes in Africa with Long-acting Antiretrovirals Long-acting (LA) injectable therapy for the treatment of Human Immunodeficiency Virus (HIV)-1 infection offers a reduced dosing frequency and an additional option…
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ENRICH+

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Neurocognitive impairment (NCI) is one of the most prevalent and deleterious complications observed in adolescents and young adults (AYA) with perinatally acquired HIV (PHIV), even despite viral suppression. There are…
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