This is a phase II, randomized, double-blind, placebo-controlled clinical trial to assess the safety, tolerability, and efficacy of 24 weeks of treatment with Selgantolimod (SLGN). Intensive PK sampling will be…

In this study, the bactericidal activity and safety of 3 doses of TBAJ876 (25 mg, 50 mg, and 100 mg) in combination with Pretomanid 200 mg and linezolid 600 mg…

Standard detection methods for viral RNA in patients include RNA purification, reverse transcription and quantitative PCR (RT-qPCR). These processes are time consuming, require multiple biochemical reagents, lab-grade instruments and trained…

There is need for anti-malarial combination therapy (ACT) comprising of at least one partner drug with a new mechanism of action to reduce developing resistance. The purpose of this study…

This is an open-label single-arm study, that will provide continued access to study drug to participants who completed their participation in parent studies sponsored by Gilead Sciences US, which include;…

The aim was to test the safety, effectiveness, and pharmacokinetics of a new HIV medication, GS-9883. Participants received the new medication for 48 weeks.

This study builds on research conducted in the early 2000s that examined the relationship between hormonal contraceptive use, genital tract microbiome diversity and HIV seroconversion. Archived biological samples from the…

This collaborative research project encompasses several studies focused on HIV drug resistance among patients receiving antiretroviral therapy. The work involves genotypic resistance testing to identify mutations associated with resistance to…

This project focused on the detection and monitoring of SARS-CoV-2 in wastewater as a public health surveillance tool. The study aimed to assess the feasibility and effectiveness of wastewater-based epidemiology…

This study is a Phase III, double-blind, placebo-controlled, multi-arm platform study that will enroll participants from Brasil, Canada, Italy, Uganda, Zambia, and the United States. The first phase, involving 348…